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  • Writer's pictureLucy Dewhurst

Polynucleotides - The Science, Benefits and Potential

Polynucleotides are the latest revolutionary tools in regenerative medicine that work on a cellular level to repair tissue and boost skin quality. This injectable treatment effectively promotes skin repair, boosts collagen production, increases skin elasticity and hydration while improving overall skin radiance.

This treatment is ideal for anyone who wants a highly effective treatment that is as natural as possible.

When injected, polynucleotides prompt the skin to repair itself. The treatment enhances blood flow and collagen production, improves hydration, and increases elasticity. ultimately reducing the visibility of wrinkles and acne scarring. Polynucleotides are highly effective at addressing dark circles under the eyes and can also treat hair loss too.

What are polynucleotides made from?

Polynucleotides are an injectable biostimulator. The stretchy molecules are made from fragments of fish which mirror human DNA.

How do polynucleotide injections work?

To have their effect, polynucleotides need to be injected beneath the skin’s surface using a fine needle. Once there, instead of directly adding volume to the skin, they work as biostimulators, targeting the fibroblasts, which play a crucial role in collagen production and wound healing.


By doing so they encourage our skin to regenerate itself from the inside out, promoting the synthesis of both collagen and elastin, and improving the condition of the extracellular matrix (the layer of the skin in which the fibroblasts live). This results in boosted hydration, reduced inflammation and improved texture, tone and firmness, meaning less visible fine lines and wrinkles over time. They aren’t finished there. Polynucleotides also scavenge up unstable molecules, called free radicals, which further helps to counteract skin ageing.

Like many other regenerative medicine tools, polynucleotides have a history of being used in general medicine before their introduction into the world of medical aesthetics. Studies have have reported their successful use for knee osteoarthritis and chronic wounds – De Caridi et al, 2016; Stagni et al, 2021

How many treatments are required?

A course of three or four treatments is recommended, three weeks part.  

When do you see the results of Polynucleotides, and how long do they last?

You start to see the results within a few days after the first session with further improvements seen after each treatment. By stimulating fibroblasts, polynucleotides boost collagen production, improve elasticity and increase hydration. They also calm inflammation and rebalance melanocyte activity to create an even and refreshed skin tone.

A clinical study involving 15 patients treated with polynucleotides found that, after 20 weeks, hydration had improved by 115% and elasticity was increased by 38%.

Results generally last around six to nine months on average before a single maintenance session is then required to prolong the results.

How do polynucleotides differ to injectable skin boosters, like Profhilo?

They are similar, but rather than just providing hydration like hyaluronic acid skin boosters, polynucleotides are highly versatile. They improve skin quality, increase skin glow, reduce pore size, improve smoothness, boost skin elasticity and moisture retention..

Polynucleotides can be applied to anyone who requires skin maintenance, skin rescue and repair, wound healing, scar improvement, reduced inflammation and importantly, skin ageing.

Who are suitable candidates for polynucleotide treatments?

It’s an animal product, so it’s not suitable for vegetarians, vegans or those with fish allergies. It’s also not appropriate for use during pregnancy or while breastfeeding. Otherwise, the natural element of this treatment, and the fact that you can inject it into any type of anatomy, means that almost anyone is a candidate provided a thorough medical history and assessment is taken prior to the treatment being performed.

Regenerative techniques are poised to revolutionise the future of aesthetic medicine in the coming years, and it's easy to see why. Polynucleotides seamlessly complement other aesthetic treatments, require minimal downtime, and present a very low risk of complications, making them a highly sought-after treatment.

Book a consultation today to learn more about what polynucleotides can do for you.

Lucy x

De Caridi G, Massara M, Acri I et al, (2016) Trophic effects of polynucleotides and hyaluronic acid in the healing of venous leg ulcers of the lower limbs.: a clinical study. Int Wound Journal.

Stagni C, Rocchi M, Mazzotta A et al, (2021) Randomised, double-blinded comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid verses hyaluronic acid alone in the treatment of knee osteoarthritis. BMC Musculoskeletal Disorder.

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